TABLE 2.
Biopsy site and Pathological features of SLONM patients
| SLONM (total = 49) | SLONM‐noMGUS (n = 34) | SLONM‐MGUS (n = 13) | SLONM‐HIV (n = 2) | |
|---|---|---|---|---|
| Biopsy site | ||||
| Upper extremity, proximal muscle | ||||
| Biceps | 26 [60.5]a | 19 [63.3]b | 7 [53.8] | NAc |
| Deltoid | 2 [4.7]a | 1 [3.3]b | 1 [7.7] | NAc |
| Lower extremity, proximal muscle | ||||
| Quadriceps, NOS | 5 [11.6]a | 4 [13.3]b | 1 [7.7] | NAc |
| Rectus femoris | 3 [7.0]a | 1 [3.3]b | 2 [15.4] | NAc |
| Vastus lateralis | 3 [7.0]a | 1 [3.3]b | 2 [15.4] | NAc |
| Semimembranosus | 1 [2.3]a | 1 [3.3]b | 0 | NAc |
| Lower extremity, distal muscle | ||||
| Gastrocnemius | 1 [2.3]a | 1 [3.3]b | 0 | NAc |
| Othersd | 2 [4.7]a | 2 [6.7]b | 0 | NAc |
| Histology | ||||
| Major type of muscle fiber‐containing nemaline bodies | ||||
| Round | 23 [46.9] | 16 [47.1] | 7 [53.8] | 0 |
| Angular | 12 [20.4] | 7 [20.6] | 3 [23.1] | 2 [100.0] |
| Cap | 6 [12.2] | 5 [14.7] | 1 [7.7] | 0 |
| Mixed | 8 [16.3] | 6 [17.6] | 2 [15.4] | 0 |
| Major type of nemaline bodies | ||||
| Rod‐like | 27 [55.1] | 18 [52.9] | 8 [61.5] | 1 [50.0] |
| Sand‐like | 15 [30.6] | 12 [35.3] | 2 [15.4] | 1 [50.0] |
| Mixed | 7 [14.3] | 4 [11.8] | 3 [23.1] | 0 |
| Intranuclear rod | 7 [14.3] | 3 [8.8] | 3 [23.1] | 1 [50.0] |
| Vacuolar change | 25 [51.0] | 18 [52.9] | 5 [38.5] | 2 [100.0] |
| Score 1 | 12 [24.5] | 8 [23.5] | 3 [23.1] | 1 [50.0] |
| Score 2 | 8 [16.3] | 5 [14.7] | 2 [15.4] | 1 [50.0] |
| Score 3 | 5 [10.2] | 5 [14.7] | 0 | 0 |
| Intermyofibrillary changes observed in NADH‐TR | 48 [98.0] | 33 [97.1] | 13 [100.0] | 2 [100.0] |
| Dark atrophic | 30 [61.2] | 22 [64.7] | 6 [46.2] | 2 [100.0] |
| Focal dark, not atrophic | 12 [24.5] | 8 [23.5] | 4 [30.8] | 0 |
| Lobulated | 16 [32.7] | 10 [29.4] | 5 [38.5] | 1 [50.0] |
| Moth‐eaten | 17 [34.7] | 14 [41.2] | 3 [23.1] | 0 |
| Other | 1 [2.0] | 1 [2.9] | 0 | 0 |
| ACP‐positive fibers | 48 [98.0] | 33 [97.1] | 13 [100.0] | 2 [100.0] |
| Score 1 | 19 [38.8] | 14 [41.2] | 4 [30.8] | 1 [50.0] |
| Score 2 | 25 [51.0] | 16 [47.1] | 8 [61.5] | 1 [50.0] |
| Score 3 | 4 [8.2] | 3 [8.8] | 1 [7.7] | 0 |
| ACP positive on myofibers‐containing nemaline bodies | 40 [81.6] | 27 [79.4] | 11 [84.6] | 2 [100.0] |
| Type 1 fiber predominance | 12 [24.5] | 9 [26.5] | 1 [7.7] | 2 [100.0] |
Abbreviations: ACP, acid phosphatase; SLONM‐HIV, SLONM associated with HIV; SLONM‐MGUS, SLONM with MGUS association; SLONM‐noMGUS, SLONM without MGUS association.
a
Information not available in six cases.
b
Information not available in four cases.
c
Information not available in two cases.
d
Sternocleidomastoid, splenius.