TABLE 4.
SLONM | SLONM‐noMGUS | SLONM‐MGUS | SLONM‐HIV | |
---|---|---|---|---|
(total = 49) | (n = 34) | (n = 13) | (n = 2) | |
Immunohistochemistry | ||||
MHCn, regenerating fibers (%) | 5.8 ± 9.3a | 5.1 ± 9.9b | 9.0 ± 7.9c | 0.65 ± 0.5 |
≤1% | 16 [36.4]a | 13 [39.4]b | 3 [27.3]c | 2 [100.0] |
>1 to ≤5% | 15 [34.1]a | 14 [42.4]b | 1 [9.1]c | 0 |
>5 to ≤10% | 5 [11.4]a | 2 [6.1]b | 3 [27.3]c | 0 |
>10% | 8 [18.2]a | 4 [12.1]b | 4 [36.4]c | 0 |
CD3 in 10 HPF | 19.4 ± 27.7b | 19.0 ± 30.6 | 19.3 ± 20.5b | 28.0 ± 22.6 |
CD8 in 10 HPF | 17.9 ± 26.4b | 18.0 ± 29.8 | 17.8 ± 17.0b | 18.0 ± 17.0 |
CD20 in 10HPF | 2.1 ± 4.6c | 1.7 ± 3.7 | 3.2 ± 6.8c | 0 |
CD68 in 10HPF | 99.9 ± 94.3b | 105.1 ± 104.8 | 89.0 ± 63.4b | 78.0 ± 87.7 |
HLA‐ABC | 32 [66.7]b | 23 [67.6] | 8 [66.7]b | 1 [50.0] |
Score 1 | 10 [20.8]b | 5 [14.7] | 5 [41.7]b | 0 |
Score 2 | 13 [27.1]b | 9 [26.5] | 3 [25.0]b | 1 [50.0] |
Score 3 | 9 [18.8]b | 9 [26.5] | 0b | 0 |
HLA‐DR | 1 [2.1]b | 0 | 1 [8.3]b | 0 |
MAC capillary deposition | 29 [60.4]b | 21 [61.8] | 6 [50.0]b | 2 [100] |
Score 1 | 19 [39.6]b | 11 [32.4] | 6 [50.0] b | 2 [100] |
Score 2 | 8 [16.7]b | 8 [23.5] | 0b | 0 |
Score 3 | 2 [4.2]b | 2 [5.9] | 0b | 0 |
MAC sarcolemmal deposition | 6 [12.5]b | 5 [14.7] | 1 [8.3]b | 0 |
Score 1 | 2 [4.2]b | 2 [5.9] | 0b | 0 |
Score 2 | 3 [6.3]b | 2 [5.9] | 1 [8.3]b | 0 |
Score 3 | 1 [2.1]b | 1 [2.9] | 0b | 0 |
MAC capillary/sarcolemmal deposition, mixed | 9 [18.8]b | 7 [20.6] | 2 [16.7]b | 0 |
p62 (fine granular pattern) | 36 [78.3]a | 26 [78.8]b | 8 [72.7]c | 2 [100] |
Score 1 | 6 [13.0]a | 4 [12.1]b | 2 [18.2]c | 0 |
Score 2 | 12 [26.1]a | 10 [30.3]b | 2 [18.2]c | 0 |
Score 3 | 18 [39.1]a | 12 [36.4]b | 4 [36.4]c | 2 [100] |
Abbreviations: CD, cluster of differentiation; HLA‐ABC, human leukocyte antigen‐ABC; HLA‐DR, human leukocyte antigen‐DR; HPF, high power field (40x objective); MAC, membrane attack complex (C5b‐9); MHCn, neonatal myosin; p62 (STQM1); SLONM‐HIV, SLONM associated with HIV; SLONM‐MGUS, SLONM with MGUS association; SLONM‐noMGUS, SLONM without MGUS association.
Information not available in three cases.
Information not available in one case.
Information not available in two cases.