Figure 1.

Comparison of EBOV-pseudotyped virus infectivity and neutralisation on various target cell lines. (a) Infectivity of the EBOV-pseudotyped lentiviral particles measured as relative luminescent units (RLU/mL) were assessed on 5 target cell lines. A vesicular stomatitis virus G protein (VSV-G) pseudotype was used as a positive control for the LVV system. LVV without an envelope protein (ΔEnv) was used to determine the background signal. (b) The percentage neutralisation of dilutions of monoclonal antibodies P6 or CA45 (μg/mL) and WHO IS (20/262; mIU/mL) following incubation with 50 TCID₅₀ of EBOV-pseudotyped virus on each of the target cells, with the fit (R²) of the dose-response curve annotated. Error bars indicate SEM (n = 2).