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. 2021 Aug 19;26(16):5010. doi: 10.3390/molecules26165010

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Tributyltin(IV) butyrate (BT2) reduces the effect of the HDAC inhibitor SAHA on histone acetylation. The figure shows Western blot analysis of acetylated-H3 and H4 histones after cell treatment for 48 h with 0.5 μM BT2 (lane 2) or 24 h treatment with 10 μM SAHA used alone (lane 4) or after pre-treatment with BT2 (24 h) followed by other 24 h of incubation with the HDAC inhibitor (lane 3). The ratio between acetylated histones and total histone levels was quantified. Representative blots of three independent experiments and densitometric analysis are shown. (*) p-value < 0.05; (***) p-value < 0.001 compared with untreated cells. N.S. = not significant.