Skip to main content
. 2021 Feb 15;31(4):e12929. doi: 10.1111/bpa.12929

FIGURE 3.

FIGURE 3

Diagnosis and grade changes from 2016 WHO Classification with cIMPACT‐NOW updates to integrative radio‐histo‐molecular assessment. Integrated radio‐histo‐molecular classification. AIII‐IDHmut: grade 3, anaplastic astrocytoma, IDH‐mutant; AIII‐IDHwt: grade 3, anaplastic astrocytoma, IDH‐wild type; mol‐GBM: diffuse astrocytic glioma, IDH‐wild type, with molecular features of glioblastoma ; periph‐GBM‐IDHmut: periphery of grade IV, glioblastoma, IDH‐mutant; periph‐GBM‐IDHwt: periphery of grade IV, glioblastoma, IDH‐wild type; GBM‐IDHwt, CE−, MVP−: grade 4 glioblastoma IDH‐wild type, without contrast enhancement (CE) and microvascular proliferation; GBM‐IDHwt, CE+, MVP−: grade 4 glioblastoma IDH‐wild type, with CE but without microvascular proliferation in a representative sample. Kaplan–Meier estimates of overall survival (OS) according to our integrated radio‐histo‐molecular classification. Concerning AIII‐IDHwt (left), the median OS was longer in patients with AIII‐IDHwt (29 months) than patients with periph‐GBM‐IDHwt (2.6 months), without reaching statistical significance (p = 0.107). Concerning AIII‐IDHmut (middle), the median OS was significantly longer in patients with AIII‐IDHmut (not reached) than patients with periph‐GBM‐IDHmut (23.1 months) (p = 0.010). Concerning mol‐GBM (right), the median OS was longer in patients with GBM‐IDHwt, CE+, MVP− (18.7 months), than patients with GBM‐IDHwt, CE−, MVP− (13.9 months), and than patients with periph‐GBM‐IDHwt (9.6 months), without reaching statistical significance (p = 0.197)