TABLE 3.
Survival analyses according to the histopathological classification (n = 629)
| Classification | n | Progression‐free survival | Overall survival | ||||
|---|---|---|---|---|---|---|---|
| Mean ± SD | Median | CI 95% | Mean ± SD | Median | CI 95% | ||
| WHO 2016 classification + cIMPACT‐NOW updates | |||||||
| Grade 2 astrocytomas, IDH‐wild type | 0 | – | – | – | – | – | – |
| Grade 2 astrocytomas, IDH‐mutant | 32 | 34.5 ± 3.3 | 35.9 | 23.1–41.1 | 91.4 ± 3.8 | 98.8 | nr–nr |
| Grade 3 anaplastic astrocytomas , IDH‐wild type | 6 | 29.6 ± 15.9 | 21.4 | 2.5–73.3 | 28.3 ± 17.0 | 8.1 | 0–105.4 |
| Grade 3 anaplastic astrocytomas, IDH‐mutant | 25 | 34.9 ± 6.4 | 30.5 | 7.7–58.8 | 57.7 ± 4.7 | 70.8 | 60.8–nr |
| Grade 4 glioblastomas, IDH‐wild type | 514 | 13.1 ± 0.6 | 10.0 | 9.0–11.0 | 18.9 ± 1.0 | 13.5 | 12–15.9 |
| Grade 4 glioblastomas, IDH‐mutant | 28 | 32.0 ± 5.5 | 23.0 | 17.0–35.3 | 56.6 ± 6.7 | 47.0 | 35.3–nr |
| Grade 4 diffuse midline gliomas, H3K27M‐mutant | 3 | 4.5 ± 3.6 | 4.5 | 0.9–8.0 | 5.3 ± 3.1 | 2.9 | 1.7–11.4 |
| Grade 4 diffuse astrocytic gliomas, IDH‐wild type, with molecular features of glioblastoma | 21 | 11.8 ± 2.7 | 8.0 | 4.9–9.8 | 17.6 ± 3.5 | 12.2 | 7.3–23.1 |
| Integrated radio‐histo‐molecular classification | |||||||
| Grade 2 astrocytomas, IDH‐wild type | 0 | – | – | – | – | ‐ | – |
| Grade 2 astrocytomas, IDH‐mutant | 32 | 34.5 ± 3.3 | 35.9 | 23.1–41.1 | 91.4 ± 3.8 | 98.8 | nr–nr |
| Grade 3 anaplastic astrocytomas, IDH‐wild type | 4 | 38.6 ± 18.5 | 32.6 | 10.1–73.3 | 41.1 ± 23.6 | 29.0 | 1.0–105.4 |
| Grade 3 anaplastic astrocytomas, IDH‐mutant | 22 | 39.7 ± 7.1 | 33.9 | 4.6–64.9 | 61.2 ± 5.0 | nr | 60.8–nr |
| Grade 4 glioblastomas, IDH‐wild type | 514 | 13.1 ± 0.6 | 10.0 | 9.0–11.0 | 18.9 ± 1.0 | 13.5 | 12.0–15.9 |
| Grade 4 glioblastomas, IDH‐mutant | 31 | 30.2 ± 4.9 | 23.0 | 14.0–35.3 | 53.9 ± 6.0 | 47.0 | 35.3–88.2 |
| Grade 4 diffuse midline gliomas, H3K27M‐mutant | 3 | 4.5 ± 3.6 | 4.5 | 0.9–8.0 | 5.3 ± 3.1 | 2.9 | 1.7–11.4 |
| Grade 4 diffuse astrocytic gliomas, IDH‐wild type, with molecular features of glioblastoma and without microvascular proliferation | 4 | 17.6 ± 7.4 | 11.0 | 8.8–39.6 | 26.4 ± 10.4 | 18.7 | 11.3–56.8 |
| Periphery of grade 4 glioblastomas, IDH‐wild type | 11 | 10.6 ± 3.9 | 7.2 | 2.5–9.2 | 11.2 ± 3.8 | 9.6 | 0–18.8 |
| Early‐stage grade 4 glioblastomas, IDH‐wild type | 8 | 7.8 ± 3.3 | 4.8 | 3.0–24.0 | 16.3 ± 4.9 | 13.9 | 16.0–19.1 |
Abbreviations: CI 95%, 95% confidence interval; nr: not reached; SD: Standard deviation.