Skip to main content
. 2021 Sep 2;16(9):e0256972. doi: 10.1371/journal.pone.0256972

Fig 7. No effects of the anti-NMDAR1 autoantibodies on fear conditioning.

Fig 7

(A) In Day1 fear acquisition, there is neither sex (F(1,31) = 0.35, p = 0.56) nor autoantibody (F(1,31) = 0.51, p = 0.48) effect on post-shock freezing time. (B) Neither sex (F(1,31) = 1.93, p = 0.17) nor autoantibody (F(1,31) = 0.61, p = 0.44) effect was observed during CS tone. (C) In Day2 context memory, female mice have significant higher freezing percentages (F(1,35) = 5.2, p = 0.029) than the male mice, but there is no autoantibody effect (F(1,35) = 0.9, p = 0.35). (D) In Day3 fear extinction, there is a trend of sex effect (F(1,35) = 2.94, p = 0.095), but without autoantibody effect (F(1,35) = 0.04, p = 0.85). CS0: pre-tone. (E) In Day4 recall of fear extinction, neither sex (F(1,35) = 0.24, p = 0.63) nor autoantibody (F(1,35) = 0.24, p = 0.63) effect was observed. CS0: pre-tone. All data are present as Mean+SEM.