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. 2021 Sep 2;16(9):e0256972. doi: 10.1371/journal.pone.0256972

Fig 10. Effects of the anti-NMDAR1 autoantibodies on fear conditioning in the large replication cohort.

Fig 10

(A) In Day 1 fear acquisition, there is neither sex (F(1,36) = 0.16, p = 0.69) nor autoantibody (F(1,36) = 0.45, p = 0.51) effect on post-shock freezing time. (B) Neither sex (F(1,36) = 1.79, p = 0.19) nor autoantibody (F(1,36) = 0.53, p = 0.47) effect was observed during CS tone. (C) In Day 2 context memory, neither sex (F(1,35) = 2.05, p = 0.16) nor autoantibody (F(1,35) = 0.55, p = 0.46) effect was observed. (D) In Day 3 fear extinction, there is no sex effect (F(1,35) = 0.25, p = 0.62) or autoantibody effect (F(1,35) = 0.52, p = 0.48). CS0: pre-tone. (E) In Day 4 recall of fear extinction, neither sex (F(1,35) = 1.26, p = 0.27) nor autoantibody (F(1,35) = 2, p = 0.17) effect was observed. However, there is a significant interaction (F(12,420) = 2.96, p = 0.00056) between the autoantibody and CS. CS0: pre-tone. All data are present as Mean+SEM.