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. 2021 Aug 23;17(8):e1009775. doi: 10.1371/journal.pgen.1009775

Fig 9. Model for 3´UTR-mediated post-transcriptional regulation of mex-3 in the germline.

Fig 9

The endogenous 3´UTR is required for the spatiotemporal expression pattern of MEX-3. Deletion of majority of the 3’UTR causes increased GFP expression throughout the germline. DAZ-1 indirectly regulates expression of MEX-3 in the distal mitotic end. GLD-1 represses MEX-3 expression through its 3´UTR in the meiotic pachytene region. LIN-41 represses expression of MEX-3 in the loop region while OMA-1/2 repress expression of MEX-3 in the maturing oocytes. Cytoplasmic polyadenylation positively regulates expression of MEX-3 in the distal mitotic end. Cytoplasmic deadenylation negatively regulates expression of MEX-3 in the distal mitotic end. IFE-3 negatively regulates expression of MEX-3 in the meiotic pachytene region.