Table 2. Association of polygenic risk scores for ADHD (primary analysis) and other psychiatric disorders (exploratory analysis) with sex of individuals with anxiety and depression in a) the whole NCMH sample and b) the sub-group of NCMH individuals with early age at onset.
| PRS | Whole sample (N = 1,315) | Early-onset sample (N = 420) | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | R2 | OR (95% CI) | P | R2 | |
| ADHD | 1.03 (0.92–1.15) | 0.63 | 2.3 x 10−4 | 1.14 (0.91–1.43) | 0.24 | 4.9 x 10−3 |
| ANX | 0.94 (0.84–1.05) | 0.28 | 1.2 x 10−3 | 0.75 (0.60–0.95) | 0.017 | 0.021 |
| ASD | 1.08 (0.96–1.21) | 0.21 | 1.7 x 10−3 | 1.04 (0.84–1.30) | 0.73 | 4.1 x 10−4 |
| BD | 1.01 (0.90–1.14) | 0.83 | 4.7 x 10−5 | 0.92 (0.74–1.15) | 0.46 | 1.6 x 10−3 |
| MDD | 1.01 (0.90–1.13) | 0.84 | 4.0 x 10−5 | 0.92 (0.73–1.16) | 0.48 | 1.9 x 10−3 |
| SCZ | 0.94 (0.84–1.05) | 0.29 | 1.1 x 10−3 | 0.77 (0.61–0.96) | 0.020 | 0.019 |
ADHD: attention deficit hyperactivity disorder; ANX: anxiety disorders; ASD: autism spectrum disorder; BD: bipolar disorder; MDD: major depressive disorder; SCZ: schizophrenia. Males are coded as 0, females are coded as 1; therefore OR>1 indicates a higher PRS in females. Bonferroni corrected p-value threshold for exploratory analyses: p<0.01 (based on 0.05/5 tests).