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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Adv Ther (Weinh). 2021 Jul 22;4(8):2100093. doi: 10.1002/adtp.202100093

Figure 3.

Figure 3.

PTT-vaccine combination for the treatment of large primary tumors and pre-established experimental metastasis. (A) Schematic of treatment regimen. (B) Local temperature increase in the tumors during laser irradiation. (C-F) Average tumor growth of the treated primary tumors (C) and untreated contralateral tumors (D), and the overall Kaplan–Meier survival curves (E). (F) Individual tumor growth with fraction of complete tumor regression (CR). The data show mean ± s.d. (B) or s.e.m. (C,D), with n = 5 (PBS + laser) or n = 7 (other groups) for (B-F). *P < 0.05, **P < 0.01, and ***P < 0.001, analyzed by two-way ANOVA with Bonferroni multiple comparisons post-test (B-D), or by log-rank (Mantel–Cox) test (E). *, # in (B) indicate statistically significant differences between PBS + laser vs. SGNP or Combo + laser (*); and Adpgk + pIC + CpG + laser vs. SGNP or Combo + laser (#). * in (C and E) indicate statistically significant differences compared with Combo + laser. *, # in (D) indicate statistically significant differences between PBS + laser vs. Combo + laser (*); and SGNP + laser vs. Combo + laser (#).