Table 2.
Reactogenicity in patients compared to healthy controls
| None | Mild | Moderate | Severe | Grade 4 | Total (%) | NEJM [6] (%) | OR | 95% CI | |
|---|---|---|---|---|---|---|---|---|---|
| Pain at injection site | 26.6 | 56.0 | 16.0 | 1.1 | 0.3 | 73.4 | 66 | 1.4 | 1.1–1.9 |
| Redness | 79.8 | 17.0 | 2.5 | 0.7 | – | 20.2 | 7 | 3.4 | 2.4–4.7 |
| Swollen | 73.4 | 21.3 | 4.3 | 1.0 | – | 26.6 | 7 | 4.8 | 3.5–6.5 |
| Fever | 83.0 | 8.1 | 6.4 | 2.5 | 17.0 | 11 | 1.7 | 1.2–2.3 | |
| Fatigue | 30.9 | 25.5 | 32.3 | 10.6 | 0.7 | 69.1 | 51 | 2.2 | 1.7–2.8 |
| Headache | 47.9 | 28.0 | 18.1 | 6.0 | – | 52.1 | 39 | 1.7 | 1.3–2.2 |
| Chills | 70.2 | 16.7 | 8.5 | 4.3 | 0.3 | 29.8 | 23 | 1.4 | 1.1–1.9 |
| Muscular pain | 58.2 | 20.9 | 15.3 | 5.3 | 0.3 | 41.8 | 29 | 1.8 | 1.4–2.3 |
| Joint pain | 65.3 | 14.5 | 14.2 | 5.3 | 0.7 | 34.7 | 19 | 2.3 | 1.7–3.0 |
| Vomiting | 97.2 | 2.8 | – | – | – | 2.8 | 1 | 2.9 | 1.2–6.5 |
| Diarrhea | 92.2 | 5.7 | 1.8 | 0.3 | – | 7.8 | 8 | 1.0 | 0.6–1.5 |
| Use of antipyretic medicine | 22.3 | 38 | 0.5 | 0.3–0.6 |