Figure 7. The H₂O₂ scavenging capability of CONP/alginate coatings on hydrogels was dependent on coating parameters, after repeated exposure to the exogenous H₂O₂.

Change in H₂O₂ levels following repeated exposure of 6-layer (A) and 12-layer (B) coated microbeads. Three incubation periods of distinct 100 μM H₂O₂ challenges are shown in three compounded bars 1^st (bottom), 2^nd (middle), and 3^rd (top). The statistics for the sum of total H₂O₂ consumed after three H₂O₂ challenges are shown above the bars. Differences in scavenging capabilities between H₂O₂ challenges are represented as tau (τ), where τ τ τ τ p < 0.0001, τ τ τ p < 0.001, τ τ p < 0.01, and τ p < 0.05. The amount of H₂O₂ scavenged per total cerium content is shown for 6-layer (C) and 12-layer (D) beads. For all graphs, statistical differences are represented as two-way and one-way ANOVA with Tukey's post-hoc test: ****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05, where * represents differences between groups, τ compares H₂O₂ scavenged between challenges, Δ compares six-and twelve-layer coatings, and γ compares groups with same alginate MW but varying pH of CONP.