Table 2. Mutants of seven Rho-GAP genes in the 12 tumor types in TCGA.

The mutants were identified from the TCGA mutation database in the GDC Data Portal. (A)All codon mutations for each gene. (B)Missense mutations for each gene. * Total = total mutations in DLC1–3 and the other 7 Rho-GAPs.

A
TUMOR	AVG MU	ARHGAP35 (P190A)		ARHGAP5 (P190B)		ARHGAP6		ARHGAP18		ARHGAP21		ARHGAP26		ARHGAP28		Total
		MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT
UTERINE	955	100	18.87	52	9.81	38	7.17	25	4.72	67	12.64	29	5.47	32	6.04	185	34.91
MELANOMA	495	19	4.07	19	4.07	21	4.5	11	2.36	28	6.00	21	4.50	15	3.21	133	28.48
COLON	425	23	5.76	23	5.76	12	3.01	9	2.26	27	6.77	7	1.75	20	5.01	99	24.81
STOMACH	330	19	4.35	28	6.41	12	2.75	5	1.14	10	2.29	6	1.37	13	2.97	101	23.11
RECTUM	312	4	2.92	5	3.65	2	1.46	3	2.19	8	5.84	4	2.92	2	1.46	21	15.33
LUNG AD	254	18	3.17	14	2.47	18	3.17	5	0.88	21	3.70	3	0.53	3	0.53	118	20.81
LUNG SC	250	29	5.89	12	2.44	11	2.24	5	1.02	15	3.05	3	0.61	6	1.22	123	25.00
ESOPHAGUS	133	4	2.17	5	2.72	1	0.54	0	0.00	7	3.80	1	0.54	7	3.8	32	17.39
PANCREAS	112	1	0.56	3	1.69	2	1.12	1	0.56	3	1.69	0	0.00	1	0.56	7	3.93
LIVER	94	6	1.65	4	1.10	2	0.55	1	0.27	1	0.27	2	0.55	0	0.00	24	6.59
BREAST	78	15	1.52	10	1.01	4	0.41	5	0.51	13	1.32	8	0.81	7	0.71	72	7.30
PROSTATE	40	2	0.40	4	0.81	1	0.20	1	0.20	4	0.81	1	0.20	1	0.20	14	2.83
B
TUMOR	AVG MU	ARHGAP35 (P190A)		ARHGAP5 (P190B)		ARHGAP6		ARHGAP18		ARHGAP21		ARHGAP26		ARHGAP28		Total
		MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT	MU	PCT
UTERINE	955	52	9.81	41	7.74	33	6.23	19	3.58	55	10.38	24	4.53	28	5.28	137	25.85
MELANOMA	495	16	3.43	19	4.07	21	4.50	10	2.14	24	5.14	21	4.50	14	3.00	123	26.34
COLON	425	19	4.76	10	2.51	10	2.51	6	1.50	20	5.01	4	1.00	15	3.76	79	19.8
STOMACH	330	14	3.2	9	2.06	9	2.06	2	0.46	8	1.83	4	0.92	11	2.52	79	18.08
RECTUM	312	4	2.92	3	2.19	2	1.46	3	2.19	7	5.11	4	2.92	2	1.46	18	13.14
LUNG AD	254	13	2.29	13	2.29	16	2.82	2	0.35	17	3.00	3	0.53	1	0.18	97	17.11
LUNG SC	250	18	3.66	7	1.42	8	1.63	4	0.81	13	2.64	3	0.61	6	1.22	100	20.33
ESOPHAGUS	133	3	1.63	5	2.72	1	0.54	0	0.00	6	3.26	1	0.54	6	3.26	30	16.30
PANCREAS	112	1	0.56	1	0.56	2	1.12	1	0.56	3	1.69	0	0.00	1	0.56	5	2.81
LIVER	94	5	1.37	3	0.82	2	0.55	1	0.27	1	0.27	0	0.00	0	0.00	19	5.22
BREAST	78	5	0.51	8	0.81	4	0.41	5	0.51	13	1.32	7	0.71	7	0.71	57	5.78
PROSTATE	40	1	0.20	4	0.81	1	0.20	1	0.20	3	0.61	1	0.20	0	0.00	12	2.42