Table 2.
Univariate Analysis and Multivariate Analysis of Factors Associated with OS Using a Cox Regression Model for Patients Who Underwent CRS in Our Center
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| 95% CI | P-value | 95% CI | P-value | |
| Age | ||||
| <60 | ||||
| ≥60 | 0.934 (0.565–1.546) | 0.792 | ||
| Sex | ||||
| Female | ||||
| Male | 1.138 (0.872–1.485) | 0.342 | ||
| Primary cancer | ||||
| Colon cancer | ||||
| Rectal cancer | 1.562 (0.903–2.701) | 0.111 | ||
| Time of BMs | ||||
| Synchronous BMs | ||||
| Metachronous BMs | 0.285 (0.100–0.810) | 0.018 | 0.802 (0.231–2.783) | 0.728 |
| Extracranial metastasis | ||||
| None | ||||
| Yes | 1.910 (1.054–3.460) | 0.033 | 1.389 (0.709–2.720) | 0.338 |
| Location of BM | ||||
| Supratentorial | ||||
| Infratentorial | 1.726 (0.767–3.888) | 0.187 | ||
| Combination | 1.356 (0.789–2.329) | 0.271 | ||
| Number of brain lesions | ||||
| 1 | ||||
| ≥2 | 1.105 (0.858–1.424) | 0.440 | ||
| The maximal dimension of BM (cm) | ||||
| <3 | ||||
| ≥3 | 0.692 (0.410–1.166) | 0.166 | ||
| CEA | ||||
| Negative | ||||
| Positive | 0.440 (0.161–1.199) | 0.109 | ||
| Unknown | 0.786 (0.304–2.033) | 0.620 | ||
| CA199 | ||||
| Negative | ||||
| Positive | 1.857 (1.048–3.293) | 0.034 | 0.717 (0.233–2.205) | 0.562 |
| Unknown | 1.972 (0.757–5.139) | 0.165 | 1.164 (0.130–10.443) | 0.892 |
| CA125 | ||||
| Negative | ||||
| Positive | 3.663 (1.817–7.386) | <0.001 | 1.941 (0.719–5.244) | 0.191 |
| Unknown | 2.076 (0.801–5.379) | 0.133 | ||
| CA242 | ||||
| Negative | ||||
| Positive | 2.066 (1.132–3.770) | 0.018 | 1.344 (0.417–4.331) | 0.620 |
| Unknown | 2.053 (0.846–4.983) | 0.112 | 1.919 (0.246–14.969) | 0.534 |
| CA211 | ||||
| Negative | ||||
| Positive | 2.226 (1.191–4.160) | 0.012 | 1.786 (0.846–3.771) | 0.128 |
| Unknown | 2.088 (0.859–5.077) | 0.104 | ||
| Treatment | ||||
| Surgery | ||||
| Conservative | 2.229 (1.323–3.757) | 0.003 | 1.861 (1.007–3.441) | 0.048 |
Notes: Statistically significant P-values are presented in bold. P-values that are not statistically significant are presented in italics.
Abbreviations: OS, overall survival; HR, Hazard Ratio; CI, Confidence Interval.