Table 6. Free parameters and their values used in the simulations.

Parameter	Description	Value
$N_{\text{NR}}$	Number of histones in nucleation region	6
$N_{\text{p}}$	Maximum number of proteins in assembly	17
$N_{gen}^x$ $N_{gen}^y$	Number of cell cycles in cold conditions Number of cell cycles post cold	8.7 43.6
$k_{\text{me}}$ $k_{\text{me}}^{high}$ $k_{\text{me}}^{low}$	PRC2-mediated methylation rate (me2 to me3) High rate (histone−1 s−1) Low rate (histone−1 s−1)	${\displaystyle \begin{array}{l}4\cdot {10}^{-5}\\ 1.7\cdot {10}^{-5}\end{array}}$
${\text{k}}_{\text{p-me}}$	Assembly-mediated methylation rate (histone−1 s−1)	0.01
${\displaystyle {\gamma }_{VIN3}}$	Noisy addition of protein to the assembly (s−1)	${1.8\bullet 10}^{-4}$
$w_0$	Timescale for VIN3 binding saturation in weeks	3
$k_{bind}$	Protein feedback rate (s−1)	0.05
${\gamma }_{\text{unbind}}$	Noisy unbinding of proteins from the assembly (protein−1 s−1)	10-3
$v$	Number of proteins in assembly required for protein feedback	4
$\alpha$ = ${\alpha }_w$ $\alpha$ = ${\alpha }_c$	Trans-acting gene activation warm conditions Trans-acting gene activation cold conditions	1 0.75