Table 7. Additional parameters and equations.

P_r in the definitions of P_OFF and P_ON refer to the proportion of time (see ‘Model parameters’ section), relevant for Figure 2—figure supplement 2.

Parameter	Description	Value
$N_{sim}$	Number of simulations for a gene	4000
$t_{out}$	Time step for time course averaging (h)	1
	Definition	Reference
$P_{OFF}$	${\displaystyle P_r\left(P{\left(R_L\right)}_{\text{me2/me3}}>\frac{3P_T}{4}\right)}$	Berry et al., 2017a
$P_{ON}$	${\displaystyle P_r\left(P{\left(R_L\right)}_{\text{me2/me3}}<\frac{P_T}{4}\right)}$
$Bi$	$Bi=4P_{ON}{P}_{OFF}$	Sneppen and Dodd, 2012; Berry et al., 2017a