Fig. 9.

Illustration of the role of progranulin (GRN gene) in the molecular network activated during the early antimicrobial response in patients with septic shock at admittance to the ICU. The network was constructed using data from high-throughput sequencing followed by RT-qPCR confirmation. Red color indicates upregulation in comparison to healthy volunteers, green indicates downregulation. Color shading corresponds to log2FC values, which are reported below the molecules along with FDR-adjusted p-values. The effect of sepsis-associated upregulation of calcitonin precursors (CALC1) and its gene product procalcitonin on sortilin (SORT1), the principal binding partner of progranulin, is illustrated on the right side of the graph