Table 2.
Interpreted FICI ranges of A22 hydrochloride in combination with antibiotics against 15 clinical strains of P. aeruginosa and E. coli.
| Strains/combinations | FICI range | Synergism % (n) | Additive/Indifference % (n) | Antagonism % (n) | |
|---|---|---|---|---|---|
| P. aeruginosa (n = 15) | |||||
| A22+ | CAZ | 0.5–1 | 87 (13) | 13 (2) | 0 (0) |
| MERO | 0.5–1.5 | 80 (12) | 20 (3) | 0 (0) | |
| GEN | 0.5–1.5 | 73 (11) | 27 (4) | 0 (0) | |
| CIP | 0.375–1 | 53 (8) | 47 (7) | 0 (0) | |
| AMK | 0.5–2 | 13 (2) | 87 (13) | 0 (0) | |
| CL | 0.375–2 | 7 (1) | 93 (14) | 0 (0) | |
|
| |||||
| E. coli (n = 15) | |||||
| A22+ | CFX | 0.25–0.5 | 100 (15) | 0 (0) | 0 (0) |
| AZM | 0.18–0.75 | 93 (14) | 7 (1) | 0 (0) | |
| CIP | 0.5–1 | 33 (5) | 67 (10) | 0 (0) | |
| AMK | 0.5–3 | 13 (2) | 87 (13) | 0 (0) | |
| MERO | 0.375–1.5 | 7 (1) | 93 (14) | 0 (0) | |
| A/S | 0.5–2 | 7 (1) | 93 (14) | 0 (0) | |
FICI: fractional inhibitory concentration index, n: number of strains. Antibiotics abbreviations: amikacin (AMK), ampicillin/sulbactam (A/S), azithromycin (AZM), cefoxitin (CFX), ceftazidime (CAZ), colistin (CL), ciprofloxacin (CIP), gentamicin (GEN), meropenem (MERO).