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. 2021 Jul 16;40(35):5367–5378. doi: 10.1038/s41388-021-01944-w

Fig. 1. Dex exacerbates breast cancer lung metastasis in vivo.

Fig. 1

A Mice treatment scheme. B Tumor volume (n = 6 mice per group). C Tumor weight at the end point (n = 6 mice per group). D Overall survival (n = 10 mice per group). E Number of metastases on lung surface (n = 6 mice per group). F Typical H&E staining of lung. Mice were treated as scheme and lung metastasis was evaluated on day 3, 5, 7 after inoculation by in vivo bioluminescence (n = 5 mice per group), image of bioluminescence (G) and statistics of average radiance (H) were showed. I Typical mouse lung tissue fixed with Bouin’s fixation. J Number of metastases on lung surface in 4T1-luc experimental metastasis model (n = 5 mice per group). Mean ± SEM is shown. *p < 0.05, **p < 0.01, ***p < 0.001; ns no statistical significance.