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. 2021 Jul 16;40(35):5367–5378. doi: 10.1038/s41388-021-01944-w

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The expression of SGK1 in 4T1 cells after Dex treatment. B The expression of SGK1 in 4T1 tumor tissue. C The SGK1 expression after Dex/Wortmannin treatment. D The influence of SGK1 inhibitor GSK650394 on the migration of 4T1 cells. The scale bar is 25 μm, n = 3 replicates. E Treatment scheme. F Tumor growth. (n = 8 mice per group). G The number of metastases on lung surface (n = 8 mice per group). H, I The effect of GSK650394 on experimental lung metastasis model. H Representative image of bioluminescence and statistics were shown (n = 3 mice per group). I The number of metastases on lung surface (n = 5 mice per group). J, K 4T1 cells were treated with Dex/ GSK650394 in vitro for 48 h before inoculation via intravenous injection. J Representative image of bioluminescence and statistics were shown (n = 3 mice per group). K The number of metastases on lung surface (n = 5 mice per group). Mean ± SEM is shown. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.