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. 2021 Jul 16;40(35):5367–5378. doi: 10.1038/s41388-021-01944-w

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The expression of CTGF in 4T1 cells after Dex treatment. B The concentration of CTGF in 4T1 cell supernatant after Dex treatment (24 h). C The expression of CTGF in 4T1 tumor tissue. D The effect of CTGF knockdown using shRNA on 4T1 cell migration, n = 3 replicates, the scale bar is 25 μm. E Representative image of bioluminescence and average radiance in experimental lung metastasis (n = 3 mice per group). F Typical mouse lung tissue fixed with Bouin’s fixation and the number of metastases on lung surface (n = 5 mice per group). G Survival (n = 6 mice per group). H The expression of Itgα6 and Itgβ1 in 4T1 cells in vitro, n = 3 replicates. Mean ± SEM is shown. *p < 0.05, **p < 0.01, ***p < 0.001; ns no statistical significance.