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. 2021 Jul 16;40(35):5367–5378. doi: 10.1038/s41388-021-01944-w

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The expression of CTGF after SGK1 knockout using CRISPR/Cas9, n = 3 replicates. B The expression of SGK1 after CTGF knockdown using shRNA, n = 3 replicates. C Schematic diagram of the molecular regulatory network between SGK1 and CTGF. D The expression of Nedd4l, p-Nedd4l, Smad2 and p-Smad2 after SGK1 knockout. E The mechanism of Dex-induced lung metastasis. F The correlation between SGK1 and CTGF expression in breast cancer. Mean ± SEM is shown. ***p < 0.001, ****p < 0.0001; ns no statistical significance.