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. 2021 May 23;12(3):1155–1158.e4. doi: 10.1016/j.jcmgh.2021.05.009

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The FoxL1 promoter drives Cre recombinase and reporter expression in tissues of the gastrointestinal tract. (A) Timeline of tamoxifen injection and tissue-harvesting scheme. (B) Immunohistochemistry of gastrointestinal regions from FoxL1^CreER-tdTomRosa26^Sun1GFP/+ mice (n = 3). Cre activity induces Sun1GFP expression in the nuclear envelopes of subepithelial mesenchymal cells. Boxed regions are shown at higher magnification (right). Co-localization of FoxL1 protein and Sun1GFP is observed (arrows). Scale bars: 50 μm. (C) Recombination efficiency was quantified as the percentage of Sun1GFP⁺FoxL1⁺ cells normalized by the total number of FoxL1⁺ cells. Recombination efficiency increased slightly along the proximal-to-distal axis of the small intestine, with the lowest recombination efficiency observed in the duodenum and the highest observed in the ileum. Error bars represent means with SEM (n = 3). TM, tamoxifen.