Supplementary Figure 1.

Spontaneous duodenal tumors in the presence or absence of EGFR in Lrig1 null mice. H&E staining for spontaneous duodenal tumors in Lrig1^Cre/Cre;Egfr^flox/flox;R26R^YFP treated with corn oil (A) or TAM (B). Black lines correspond to enlarged micrographs in Figure 1B. Scale bar = 500 μm. (C) Immunofluorescence for YFP (green, anti-GFP staining) with DAPI (purple). YFP expression indicates the cells in which Lrig1^Cre-driven recombination occurs. Scale bar = 100 μm. CTL, control.