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. 2021 Apr 9;73(4):1033–1051. doi: 10.1007/s43440-021-00251-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Chemical structures of discussed ligands. The figure presents chemical structures of agonists in the order they are discussed in the article: TRV130 (Oliceridine), kratom alkaloids, kurkinorin, carfentanil-amide opioids (MP102 as an exemplary member of this family of compounds), PZM21 and piperidine benzimidazoles (SR-compounds; SR-14968 and SR-17018 were chosen and discussed as the most interesting and promising compounds from this group)