Fig. 2.

Potential divergent effects of specific IL-6 signalling pathways on depression risk.

Note: Fig. 2a shows IL-6 classic and trans-signalling pathways; see review by Hunter and Jones [51]. Fig. 2b displays our working hypothesis arising from MR results that IL-6 trans-signalling confers increased risk for depression. ¹MR estimates are based on 2-sample MR analysis using Georgakis et al. [38] genetic instruments and continuous depressive symptoms as outcome (cf. Table 4). Abbreviations: gp130=glycoprotein 130; Dep.=depression; CRP=C-reactive protein; IL-6=interleukin-6.