Table 4.

IVW Mendelian randomisation analysis of association of IL-6 and CRP with depression and anxiety.

	Depression Symptom Score		Probable depression		Anxiety Symptom Score		Probable GAD
Model	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
CRP
2-Sample MR	0·88 (0·80–0·98)	0·020	0·95 (0·85–1·07)	0·424	0·87 (0·80–0·95)	0·003	0·82 (0·72–0·94)	0·004
1-Sample MR	0·89 (0·79–1·00)	0·055	1·01 (0·88–1·14)	0·939	0·88 (0·79–0·97)	0·008	0·84 (0·73–0·98)	0·027
Women	0·98 (0·85–1·12)	0·754	1·12 (0·96–1·30)	0·152	0·86 (0·76–0·98)	0·023	0·85 (0·72–1·01)	0·059
Men	0·78 (0·63–0·96)	0·018	0·84 (0·66–1·06)	0·138	0·91 (0·78–1·05)	0·192	0·83 (0·62–1·11)	0·209
IL-6
2-Sample MR	1·34 (1·05–1·72)	0·019	1·15 (0·86–1·54)	0·340	1·13 (0·91–1·41)	0·269	1·24 (0·89–1·73)	0·194
1-Sample MR	1·32 (1·03–1·67)	0·025	1·18 (0·89–1·56)	0·246	1·11 (0·90–1·37)	0·313	1·18 (0·86–1·62)	0·297
Women	1·42 (1·01–1·97)	0·041	1·46 (1·00–2·13)	0·048	1·15 (0·85–1·56)	0·362	1·51 (1·01–2·25)	0·044
Men	1·24 (0·88–1·74)	0·218	0·86 (0·54–1·37)	0·516	1·08 (0·79–1·47)	0·636	0·79 (0·47–1·33)	0·385

Note: Estimates for men and women are based on sex-stratified 1-sample MR analyses.