Table 2.
Cerebrospinal fluid markers and baseline characteristics across cognitive categories in amyloid-PET positive individuals.
| Cognitive categories | |||||||
|---|---|---|---|---|---|---|---|
| Variable | NC | N | MCI | N | AD | N | p-value |
| Aβ42 (pg/ml)* | 898.7 (367.4) | 155 | 755.4 (283.6) | 270 | 602.8 (198.2) | 171 | <0.001 |
| Aβ40 (pg/ml) | 19,656.1 (5407.0) | 75 | 17,953.3 (5293.0) | 36 | 15,941.6 (5254.7) | 19 | 0.020 |
| p-tau (pg/ml) | 28.0 (12.2) | 155 | 33.3 (15.7) | 270 | 38.1 (15.6) | 171 | <0.001 |
| t-tau (pg/ml) | 288.5 (109.1) | 155 | 332.1 (138.0) | 271 | 383.9 (147.9) | 171 | <0.001 |
| APOE4 (%) | 50.3% | 78 | 63.8% | 173 | 72.7% | 125 | <0.001 |
| Age (years) | 74.4 (6.3) | 155 | 73.4 (6.5) | 271 | 73.0 (8.2) | 172 | 0.17 |
| Education (years) | 16.5 (2.5) | 155 | 16.0 (2.8) | 269 | 15.8 (2.6) | 172 | 0.048 |
| Sex (female) (%) | 66.5% | 103 | 45.0% | 122 | 44.8% | 77 | <0.001 |
| Amyloid PET (SUVR) | 1.32 (0.18) | 155 | 1.38 (0.17) | 271 | 1.46 (0.17) | 172 | <0.001 |
| Amyloid PET (CL) | 62.3 (33.3) | 155 | 75.5 (33.2) | 271 | 90.5 (32.8) | 172 | <0.001 |
Data are expressed in mean (standard deviation) or frequency (%). APOE4: APOE ε4 allele; Aβ42: 42-amino acid β amyloid peptide; Aβ40: 40-amino acid β amyloid peptide; p-tau: phospho-Tau; t-tau: total-Tau; pg: picogram; ml: milliliters; PET: Positron Emission Tomography; SUVR: standard uptake value ratio; CL: centiloid; NC: normal cognition; MCI: mild cognitive impairment; AD: Alzheimer's disease; N/A: not available. *Post-hoc analysis: NC compared to AD (p < 0.001), NC compared to MCI (p < 0.001), and MCI compared to AD (p < 0.001).