Table 3.

Performance of prognosis models among high-risk patients with MCI.

Predictive dataset	Prognosis model	NRI (95% CI)	IDI (95% CI)
ADAS-13 (N = 110)	A1+ baseline MRI versus A1	0.123 (0.045, 0.664)*	0.003 (− 0.118, 0.093)
	A2+ baseline MRI versus A2	− 0.062 (− 0.074, 0.391)	0.006 (− 0.172, 0.172)
	A2+ ∆MRI versus A2	0.246 (0.021, 0.848)*	0.090 (− 0.094, 0.209)
MMSE (N = 92)	M1+ baseline MRI versus M1	0.177 (− 0.035, 0.902)	0.008 (− 0.085, 0.087)
	M2+ baseline MRI versus M2	0.201 (− 0.046, 0.685)	0.005 (− 0.148, 0.107)
	M2+ ∆MRI versus M2	0.489 (− 0.132, 0.878)	0.065 (− 0.062, 0.170)

A1, ADAS-13 baseline Prognosis Model; A2, ADAS-13 longitudinal Prognosis Model; M1, MMSE baseline Prognosis Model; M2, MMSE longitudinal Prognosis Model. ADAS-13, Alzheimer Disease Assessment Scale Cognitive 13 items; MMSE, Mini mental state examination; NRI, Net Reclassification Improvement; IDI, Integrated Discrimination Improvement. Values based on the following assumptions: Risk of event = 10%.

*The indices are statistically significant.