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. 2021 Sep 2;11:17604. doi: 10.1038/s41598-021-97117-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FoxO3a was repressed in human brains of ApoE4 carriers. Human postmortem brain tissues (superior temporal gyrus) were collected to compare ApoE4 non-carriers (n = 7, E4−) vs. carriers (n = 5, E4 +). The protein levels of FoxO3a, p-FoxO3a (Ser253), ApoE4, and β-actin were analyzed by immunoblotting using the corresponding antibodies, respectively. (A) shows the representative western blot analysis of FoxO3a and p-FoxO3a (Ser253). β-actin was used as a loading control. Full blots are provided in Supplementary Fig. S4. Relative ratio of FoxO3a (B) and p-FoxO3a (Ser253) (C) to the protein level of β-actin and FoxO3a, respectively. Data shown are mean ± SEM and were analyzed using the Student’s t-test. (*p < 0.05).