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. 2021 Sep 2;11:17604. doi: 10.1038/s41598-021-97117-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Autophagy/mitophagy components were quantitatively altered in the brains of ApoE4 carriers. The protein levels of p62, LC3, p-ubiquitin (Ser65), optineurin, and β-actin in ApoE4 non-carriers (n = 7, E4-) vs. carriers (n = 5, E4 +) were analyzed by immunoblotting using corresponding antibodies, respectively. Representative western blot analysis of p62 and LC3 (A), p-ubiquitin (Ser65), and optineurin (B). β-actin was used as a loading control. Full blots are provided in Supplementary Fig. S4. Relative ratio of p62 (C), LC3-II (D) p-ubiquitin (Ser65) (E), and optineurin (F) against the protein levels indicated on the y-axis, respectively. Data shown are mean ± SEM. (**p < 0.01). ns not significant.