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. 2021 Sep 2;11:17626. doi: 10.1038/s41598-021-96863-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular simulations of the chimeric protein. (a) Successive antigen injections leading to immunoglobulins production (Colored peaks indicate black vertical lines, along with other sub-classes of immune cells). (b) Post-insertion development in B-cell population per state as per observation after inserting three injections. (c) Development of T-helper cells (d) T-cytotoxic cell population per state after injections. The resting phase denotes those cells that are not presented with the antigens and energy state denotes cells that are tolerant to antigens due to repeated exposure, thereby indicating a lack of immune responsiveness.