Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 2;11:17626. doi: 10.1038/s41598-021-96863-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Multi-epitope vaccine constructs for Chagas disease. The vaccine construct consists of 24 epitope sequences, belonging to CTL, HTL and BCL epitopes of 8 T. cruzi proteins. Beta-defensin (Light purple) was used as the adjuvant and is linked to the top CTL epitope (light pink) using an EAAAK (maroon) linker. The other CTL epitopes were linked to each other using GGGS (violet) linkers. The last CTL epitope and the first HTL epitope (blue), as well as the other HTL epitopes were connected through an AAY (sky blue) linker. The last HTL epitope and the first BCL epitope (yellow) as well as the other BCL epitopes were connected through a KK (purple) linker. An EAAAK (maroon) linker was added at the end of the sequence for increasing stability (Draw.io—https://www.diagrams.net/-14.6.10).