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. 2021 Sep 2;12(9):825. doi: 10.1038/s41419-021-04110-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Normal and osteoporosis patients were arranged for X-ray (A) and MRI (B). Bone tissues form vertebral body were collected from the two groups (n = 3). Gene microarray analysis was carried out to explore the differential gene expression and shown as heat map (C). The number of upregulated and downregulated genes were shown (D). KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis were shown to identify the significant signaling pathway (E). GO enrichment analysis were carried out. CC cellular component, MF molecular function, BP biological process (F). The differential gene expression scatter plot in the two group was shown as log FPKM (Fragments Per Kilobase Million) (G). H The volcano map of differential genes was shown. The dot of Dsup6 was shown (red arrow).