. Author manuscript; available in PMC: 2021 Oct 13.

Published in final edited form as: Mol Psychiatry. 2021 Mar 3;26(7):3395–3406. doi: 10.1038/s41380-021-01051-y

Table 1.

Model effects of baseline cytokine biotypes on measures of anhedonia (SHAPS) and overall depressive symptom severity (MADRS) in patients with bipolar I/II disorder who were experiencing a current major depressive episode at the time of study enrollment. A generalized estimating equation with a negative binomial distribution and autoregressive covariance structure was used.

Model effects	SHAPS			MADRS
Model effects	df	χ ²	p	df	χ ²	p

Time	2	19.89	<0.001	3	73.66	<0.001
Treatment	1	0.005	0.946	1	0.29	0.593
Biotype	2	0.003	0.999	2	1.55	0.460
Time × Treatment	2	8.26	0.016	3	7.22	0.065
Time × Biotype	4	2.31	0.679	6	1.36	0.968
Treatment × Biotype	2	0.06	0.972	2	0.87	0.649
Time × Treatment × Biotype	4	10.40	0.034	6	5.13	0.528

Abbreviations: df: degree of freedom; MADRS: Montgomery-Asberg Depression Rating Scale (0 to 60); SHAPS: Snaith-Hamilton Pleasure Scale (14 to 56).