Table 2.

Model effects of baseline cytokine biotypes on plasma cytokine and NEV factor scores. A generalized estimating equation with a gamma distribution and exchangeable covariance structure was used.

Model effects	df	PL1		PL2		PL3		NEV1		NEV2
		χ2	p	χ2	p	χ2	p	χ2	p	χ2	p
Time	3	6.86	0.08	1.35	0.72	39.77	<0.01	16.85	<0.01	3.80	0.28
Treatment	1	0.03	0.86	0.56	0.45	24.32	<0.01	1.36	0.24	0.02	0.88
Biotype	2	437.12	<0.01	48.88	<0.01	0.44	0.80	9.62	<0.01	3.50	0.17
Time × Treatment	3	4.88	0.18	1.20	0.75	14.81	<0.01	0.85	0.84	4.26	0.24
Time × Biotype	6	22.33	<0.01	12.22	0.06	13.79	0.03	13.48	0.04	5.68	0.46
Treatment × Biotype	2	3.02	0.22	2.23	0.33	0.40	0.82	1.32	0.52	0.16	0.92
Time × Treatment × Biotype	6	17.02	<0.01	3.73	0.71	10.74	0.10	18.21	<0.01	6.57	0.36

Abbreviations: df: degree of freedom; NEV: neuronal origin-enriched extracellular vesicle factor; SHAPS: Snaith-Hamilton Pleasure Scale; PL: plasma cytokine factor; ΔSHAPS: (SHAPS_{Week 6 or 12} − SHAPS_{Week 0})/SHAPS_{Week 0}