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. 2021 Sep 2;11:17606. doi: 10.1038/s41598-021-97099-5

Figure 4.

Figure 4

Direct causal estimates of genetically predicted IL-18, IL-18BP, and IL-37 with lung cancer (LC) and its subtypes [lung adenocarcinoma (LUAD) and squamous cell lung cancer (LUSC)] using robust multivariable MR analyses. Cis-pQTLs is cis protein quantitative loci. P** indicates a pleiotropy test based on the MVMR Egger. ConF indicates the overall conditional F-statistic. The modified Q-statistic for LC, LUAD, and LUSC are respectively 28.00 (P = 0.022), 13.53 (P = 0.562), and 18.99 (P = 0.214).