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. 2021 Sep 2;7:69. doi: 10.1038/s41522-021-00242-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — We speculate a possible metabolic response analysis of three differential metabolites, in which an increase of glyceric acid and L-aspartic acid may indicate an acceleration of glycolysis and TCA cycle, and functional analysis of differential metabolites also illustrates this speculated (KO2147, KO0131). In addition, tyrosine is decomposed into dopamine and p-hydroxyphenylpyruvate, Eggerthella lenta can convert dopamine to m-tyramine, p-hydroxyphenylpyruvate is oxidized to p-hydroxyphenylacetic. Eggerthella lenta and p-hydroxyphenylpyruvate was significantly increased in A53T monkeys. G-3-P: oxidation of plyeradehyde-3-phosphate, 1,3-BPG: 1,3-triglyceric acid diphosphate, 3-PG: 3-phosphoglycerate. Yellow: metabolites, microbiota, KO increased significantly in A53T monkeys.