Figure 3.

Improvements in muscle physiology with AAV.CAPN3 gene therapy

(A and B) In vivo muscle contractility assay showing a higher force output in (A) maximum twitch and (B) tetanic responses from gastrocnemius muscle in LD and HD treatment cohorts compared with UT CAPN3 KO mice from the old age group. Data reflect all treatment groups combined (treated cohorts, n = 23; UT cohort, n = 28; WT, n = 10). (C and D) Similarly, treated mice showed increased (C) twitch and (D) tetanic responses in the young age group (treated cohorts, n = 22–23; UT cohort, n = 13). Each bar represents the mean ± SEM. ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, unpaired t test.