Figure 7.

Relative Pgc1a expression levels in muscle and its correlation with fiber type remodeling

(A, B, D, and E) Relative expression levels of Pgc1a in gastrocnemius (GAS; A and B) and TA (D and E) muscles from the old age group of CAPN3 KO (UT, n = 8; LD, n = 12; HD, n = 12) and age-matched WT (n = 8) mice 20 weeks after hCAPN3 gene delivery are shown as both sexes combined (A and D) and separated (B and E). (C and F) Line graphs showing the percent changes in fiber type (STO, FTO, and FTG) distribution in the same muscles, GAS (C) and TA (F), from the LD and HD treatment cohorts. Data are represented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, unpaired t test. A switch to STO (as percent increase) in the HD and LD cohorts was observed only in females (C and F) even though LD males showed higher Pgc1a expression than females (B and E).