FIGURE 1.

Putative mechanisms underpinning the therapeutic efficacy of lithium salts in BD. GSK3β hyperactivity, PI‐cycle dysfunction and neuroinflammation have been implicated in BD etiopathogenesis. Lithium may alleviate expression of BD symptoms through amelioration of these processes, likely though mechanisms involving displacement of magnesium (thereby limiting activity) from the catalytic cores of GSK3β and IMPase