TABLE 2.
Modified fatigue impact scale: comparisons between cannabis continuation (CC) and cannabis withdrawal (CW) groups
| Baseline | Day 28 assessment | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CW | CC | CW | |||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | rmANOVA F[df], Sig. | HADS‐D | THCCOOH‐creatinine | Duration | |
| Cognitive subscale | ||||||||||||
| Alertness | 1.85 | 1.04 | 1.37 | 1.26 | 1.70 | .865 | .89 | .658 | F[33] = .75, p = .391 | p = .002 | p = .145 | p = .482 |
| Vigilance | 1.75 | .967 | 1.53 | 1.12 | 1.60 | .883 | 1.00 | .882 | F[33] = 2.47, p = .124 | p = .017 | p = .758 | p = .859 |
| Thinking clearly | 1.80 | 1.01 | 1.84 | 1.21 | 1.65 | 1.04 | 1.42 | .838 | F[33] = .89, p = .352 | p = .003 | p = .4487 | p = .213 |
| Memory | 1.70 | .979 | 2.21 | 1.03 | 1.45 | .999 | 1.79 | .855 | F[33] = .67, p = .417 | p = .002 | p = .283 | p = .443 |
| Decision making | 1.95 | .999 | 2.21 | .976 | 1.60 | 1.04 | 2.26 | 1.24 | F[33] = .91, p = .347 | p = .003 | p = .447 | p = .769 |
| Motivationa | 1.75 | 1.25 | 2.21 | 1.13 | 1.45 | .945 | 2.53 | 1.38 | F[33] = 1.4, p = .244 | p = .002 | p = .386 | p = .529 |
| Task completion | 1.85 | 1.18 | 2.21 | .976 | 1.45 | .887 | 1.89 | 1.04 | F[33] = .03, p = .869 | p = .001 | p = .139 | p = .475 |
| Organizing thoughts | 1.95 | 1.28 | 2.00 | 1.29 | 1.50 | 1.05 | 1.53 | .772 | F[33] = .09, p = .763 | p = .003 | p = .191 | p = .666 |
| Slowed thinking | 1.70 | 1.17 | 2.00 | 1.29 | 1.40 | .995 | 1.16 | .958 | F[33] = 3.56, p = .067 | p = .002 | p = .439 | p = .859 |
| Concentration | 1.75 | 1.16 | 1.53 | 1.07 | 1.70 | .801 | 1.05 | .911 | F[33] = 2.34, p = .134 | p = .002 | p = .454 | p = .597 |
| Physical subscale | ||||||||||||
| Uncoordinated | 2.35 | 1.23 | 2.26 | .806 | 2.15 | 1.10 | 2.05 | 1.08 | F[33] = 0, p = 1.0 | p = .002 | p = .659 | p = .347 |
| Physical speed | 2.25 | 1.21 | 1.68 | 1.06 | 2.15 | 1.27 | 2.11 | 1.10 | F[33] = 2.24, p = .143 | p = .000 | p = .438 | p = .683 |
| Motivationb | 2.15 | 1.39 | 1.89 | .994 | 2.35 | 1.31 | 2.21 | .976 | F[33] = .1, p = .758 | p = .000 | p = .783 | p = .434 |
| Stamina | 2.25 | 1.16 | 2.00 | 1.00 | 2.20 | 1.20 | 2.00 | 1.20 | F[33] = .11, p = .74 | p = .000 | p = .553 | p = .256 |
| Weakness | 2.40 | 1.47 | 1.68 | 1.20 | 2.20 | 1.11 | 2.00 | 1.05 | F[33] = 1.92, p = .174 | p = .000 | p = .814 | p = .57 |
| Discomfort | 2.30 | 1.34 | 1.95 | 1.35 | 2.20 | 1.32 | 2.05 | 1.13 | F[33] = .27, p = .605 | p = .000 | p = .93 | p = .479 |
| Physical effort | 2.45 | 1.43 | 2.00 | 1.05 | 2.40 | 1.27 | 2.32 | .885 | F[33] = 1.25, p = .27 | p = .000 | p = .733 | p = .881 |
| Physical limitations | 2.10 | 1.17 | 1.74 | .872 | 2.40 | 1.10 | 1.89 | 1.24 | F[33] = .20, p = .657 | p = .000 | p = .706 | p = .196 |
| Physical rest | 1.85 | 1.23 | 1.79 | 1.18 | 2.20 | 1.06 | 1.95 | 1.03 | F[33] = .29, p = .596 | p = .000 | p = .911 | p = .164 |
| Psychosocial subscale | ||||||||||||
| MotivationC | 1.65 | 1.35 | 1.53 | 1.12 | 1.65 | 1.35 | 1.58 | 1.02 | F[33] = .98, p = .328 | p = .000 | p = .03 | p = .710 |
| Activities | 1.50 | 1.28 | 1.42 | 1.07 | 1.50 | 1.28 | 1.84 | 1.21 | F[33] = 2.86, p = .007 | p = .000 | p = .067 | p = .694 |
Abbreviations: CC = cannabis continuation group; CW = cannabis withdrawal group; df = degrees of freedom; duration = MS disease duration in years; HADS‐D = hospital anxiety and depression scale‐depression subscale; rmANOVA = repeat measures analysis of variance; SD = standard deviation; Sig‐statistical significance; THCCOOH‐creatinine = ratio of THC metabolite to creatinine in urine.
aMotivation related to anything that required thinking.
bMotivation related to physical effort.
cMotivation related to social activities. .