Table 2.
Seed‐to‐voxel results showing differences in functional connectivity between mild traumatic brain injury (mTBI) patients and healthy controls, after controlling for the effect of injury history (uncorrected threshold p < .01, false discovery rate (FDR)‐corrected threshold p < .05)
| Seed | Target(s) | Voxels | Peak MNI coordinates | Peak t statistic | p (FDR) | Direction of FC change relative to controls |
|---|---|---|---|---|---|---|
| DMN | ||||||
| Lateral parietal R | Precuneus | 226 | 10 −52 74 | −4.77 | .000014 | Hypoconnectivity |
| TPN | ||||||
| DLPFC R | Lateral occipital cortex R | 66 | 52 −62 −6 | 3.95 | .043118 | Hyperconnectivity |
| Insula R |
Lateral occipital cortex R Lateral occipital cortex L Cingulate gyrus |
92 25 58 |
−34 −86 −16 38 −78 −10 −4 −10 46 |
−5.28 |
.015997 .023159 .045050 |
Hypoconnectivity |
| SN | ||||||
| Supramarginal gyrus R |
Lateral occipital cortex R Superior parietal lobule R |
69 110 |
40 −78 16 24 −54 56 |
4.49 |
.013429 .013429 |
Hyperconnectivity |
Abbreviations: DMN, default mode network; DLPFC, dorsolateral prefrontal cortex; MNI, Montreal Neurological Institute; SN, salience network; TPN, task‐positive networks.