TABLE 4.

Significant results for a priori anatomical regions‐of‐interest (ROI) analyses. For each ROI, the cluster‐level threshold‐free cluster enhancement‐family‐wise error corrected P‐value and number of voxels in the cluster are shown, with maxima test statistics and MNI coordinates (x, y, z)

Contrast	Cluster	P	k	ROI	F/Z	x	y	z
Main effect of group	1	0.004	237	ACC	14.77	0	17	32
					12.37	0	23	20
					11.79	6	32	26
					10.51	6	5	29
					9.66	9	−7	41
Responders, scan 2 > scan 1
	1	0.007	8	Insula	3.68	−30	20	−4
	2	0.007	8	Insula	3.56	33	23	2
Responders > controls, scan 2
	1	0.001	239	ACC	4.66	−9	17	35
					4.01	6	32	26
					3.84	−3	41	17
					3.79	6	5	32
					3.39	12	14	35
	1	0.006	12	Amygdala	3.60	−27	−28	−13
					3.31	−33	−19	−13
	1	0.007	2	Insula	4.13	−36	−7	−10
	2	0.004	51	Insula	4.00	39	11	−10
					3.80	30	23	2
					3.52	39	17	2
	3	0.004	30	Insula	3.71	−36	−22	14
	4	0.005	44	Insula	3.70	−33	20	−4
	1	0.006	5	MTG	3.51	48	−25	−4
Responders > non‐responders, scan 2
	1	0.009	2	MTG	3.82	−57	−58	11

k = cluster size, F/Z = Test statistic of the maxima. F‐statistic for the main effect of group; Z‐statistic for within and between‐subjects contrasts.

ACC = anterior cingulate cortex, MTG = mid temporal gyrus.

x, y, z = MNI coordinates of maxima. The top maxima (up to 5) more than 10 mm apart reported.