Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of the potential roles of exosomal MIF in glioma TMZ resistance
The TR cells-secreted exosomes containing MIF can be taken up by the TS cells. Exosomal MIF suppresses apoptosis by downregulating TIMP3 and activating PI3K/Akt signaling pathway, resulting in enhanced cell proliferation, suppressed cell apoptosis, and promoted TMZ resistance of the recipient TS cells.
