Figure 20.

Engraftment of human leukemic cells and human lymphocytes, spleen, mouse implanted with transduced hCD34+ cells (mouse no. 17). (a) White starred areas indicate white pulp areas, black stars indicate red pulp. (b) The white pulp is populated by small lymphoid cells and the red pulp contains myeloid cells and extramedullary hematopoiesis. HE. (c–f) The white pulp contains a mixture of CD3-positive T cells (c) and PAX5-positive B cells (d). The myeloid cells in the red pulp are positive for hCD68 (e) and negative for hCD163 (f).