Table 1.
Experimental Details of 24 Affected NSG-SGM3/NRG-SGM3 Mice
| Mouse No. | Institution | Model | Sex | Age (weeks) | Implantation to Euthanasia (Weeks) | Clinical Signs |
|---|---|---|---|---|---|---|
| 1 | UC Davis | Humanized | F | 29 | 25 | Head tilt |
| 2 | UC Davis | Humanized | F | 29 | 25 | Hind limb paralysis |
| 3 | UC Davis | Humanized | F | 32 | 28 | Head tilt, lateral recumbency |
| 4 | UC Davis | Humanized | F | 29 | 25 | Ataxia, hunched posture, pallor, lethargy |
| 5 | UC Davis | Humanized | F | 15 | 11 | Pallor, lethargy, weight loss |
| 6 | UC Davis | Humanized | F | 15 | 11 | Hunched posture, pallor, weight loss |
| 7 | UC Davis | Humanized | F | 15 | 11 | Hunched posture, pallor, weight loss |
| 8 | UC Davis | Humanized | F | 26 | 22 | Head tilt, ataxia, weight loss |
| 9 | UC Davis | Humanized | F | 32 | 28 | Head tilt, ataxia |
| 10 | U Mich | Humanized | F | 36 | 32 | Pallor, lethargy, weight loss |
| 11 | U Mich | Humanized | F | 38 | 34 | Pallor, lethargy, weight loss |
| 12 | U Mich | Humanized | F | 42 | 38 | Pallor, lethargy, weight loss |
| 13 | MDA | Humanized | F | 20 | 16 | Failure to thrive |
| 14 | MDA | Humanized | F | 20 | 16 | Failure to thrive |
| 15 | St. Jude | Transduced hCD34+ HSCs | F | 20 | 12 | Hunched posture, pallor, weight loss, lethargy |
| 16 | St. Jude | Transduced hCD34+ HSCs | F | 20 | 12 | Hunched posture, pallor, weight loss, lethargy |
| 17 | St. Jude | Transduced hCD34+ HSCs | F | 26 | 18 | Hunched posture, lethargy |
| 18 | St. Jude | PDX, AEL #1 | F | 13 | 4 | Pallor, weight loss |
| 19 | St. Jude | PDX, AEL #2 | F | 14 | 5 | None reported |
| 20 | St. Jude | PDX, AEL #3 | M | 41 | 32 | None reported |
| 21a | St. Jude | PDX, AML #1 | F | 28 | 20 | None reported |
| 22a | St. Jude | PDX, AML #1 | F | 28 | 20 | None reported |
| 23a | St. Jude | PDX, AML #1 | F | 28 | 20 | None reported |
| 24a | St. Jude | PDX, AML #1 | F | 28 | 20 | None reported |
Abbreviations: UC Davis, University of California at Davis; U Mich, University of Michigan; F, female; M, male; HSCs, hematopoietic stem cells; PDX, patient derived xenograft; AEL, acute erythroid leukemia; AML, acute myeloid leukemia
a
NRG-SGM3 strain