Table 5.

CBC Values in NSG-SGM3 Mice. Representative examples for humanized mice, mice implanted with transduced hCD34+ cells and mice implanted with an AEL PDX, compared to typical values for naïve NSG-SGM3 mice.

	Naïve, Rangea	Naïve, Mean	Humanized Mouseb	Transduced hCD34+ HSCsc	Engrafted AEL PDXd
HCT, %	32.4–37.5	33.9	8.3	7.0	19.5
RBC × 106/μL	6.5–7.79	7.2	1.25	1.12	3.47
HB, g/dL	10.2–13.1	11.6	2.2	3	5.7
MCV, fL	48.1–49.8	47.2	66.2	62.5	26.1
MCH, pg	15.7–16.8	16.2	17.6	26.8	16.4
MCHC, g/dL	31.5–34.9	34.3	26.5	42.9	29.2
RETIC, x1000/ μL	12.5–120.9	54.8	N/De	126.3	123.5
RETIC %	0.16–1.86	0.8	N/D	11.28	3.56

Abbreviations: CBC, complete blood count; AEL, acute erythroid leukemia; PDX, patient derived xenograft; HSCs, hematopoietic stem cells; HCT, hematocrit; RBC, red blood cells; HB, hemoglobin; MCV, mean corpuscular volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; RETIC, reticulocyte

^aCBC values for 3 naïve NSG-SGM3 mice, showing range and mean.

^bMouse no.12

^cMouse no.16

^dMouse no. 20

^eN/D, not done