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Anti-trastuzumab-resistant tumor effects of TTF in a BT474-cell line human breast cancer xenograft model. (A) Nude mice bearing BT474R cells as xenografts were treated using control (saline), trastuzumab, TTF, combination. Treatment effects on tumor volume (B) Representative hematoxylin and eosin (H&E) staining (C) Representative of Ki-67. Data are presented as the mean ± standard error of the mean (n = 5), *P < 0.05, **P < 0.01.
